Ontology highlight
ABSTRACT:
SUBMITTER: Kefauver JM
PROVIDER: S-EPMC6086657 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kefauver Jennifer M JM Saotome Kei K Dubin Adrienne E AE Pallesen Jesper J Cottrell Christopher A CA Cahalan Stuart M SM Qiu Zhaozhu Z Hong Gunhee G Crowley Christopher S CS Whitwam Tess T Lee Wen-Hsin WH Ward Andrew B AB Patapoutian Ardem A
eLife 20180810
SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms a vastly heterogeneous cohort of VRAC channels with different properties; however, SWELL1 alone is also functional. Here, we report a high-resolution cryo-electron microscopy structure of full-length human homo-hexameric SWELL1. The structure reveals ...[more]