Ontology highlight
ABSTRACT:
SUBMITTER: Borges AL
PROVIDER: S-EPMC6086726 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cell 20180719 4
Bacteria utilize CRISPR-Cas adaptive immune systems for protection from bacteriophages (phages), and some phages produce anti-CRISPR (Acr) proteins that inhibit immune function. Despite thorough mechanistic and structural information for some Acr proteins, how they are deployed and utilized by a phage during infection is unknown. Here, we show that Acr production does not guarantee phage replication when faced with CRISPR-Cas immunity, but instead, infections fail when phage population numbers f ...[more]