Ontology highlight
ABSTRACT:
SUBMITTER: Kunzmann S
PROVIDER: S-EPMC6086851 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kunzmann Steffen S Krempl Christine C Seidenspinner Silvia S Glaser Kirsten K Speer Christian P CP Fehrholz Markus M
Influenza and other respiratory viruses 20180522 5
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV-infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV-med ...[more]