Ontology highlight
ABSTRACT:
SUBMITTER: Jaeschke H
PROVIDER: S-EPMC6087673 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jaeschke Hartmut H Duan Luqi L Akakpo Jephte Y JY Farhood Anwar A Ramachandran Anup A
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180618
Although necrosis is recognized as the main mode of cell death induced by acetaminophen (APAP) overdose in animals and humans, more recently an increasing number of publications, especially in the herbal medicine and dietary supplement field, claim an important contribution of apoptotic cell death in the pathophysiology. However, most of these conclusions are based on parameters that are not specific for apoptosis. Therefore, the objective of this review was to re-visit the key signaling events ...[more]