Ontology highlight
ABSTRACT:
SUBMITTER: Lee EY
PROVIDER: S-EPMC6087683 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lee Ernest Y EY Lee Michelle W MW Wong Gerard C L GCL
Seminars in cell & developmental biology 20180212
Antimicrobial peptides (AMPs) are typically thought of as molecular hole punchers that directly kill pathogens by membrane permeation. However, recent work has shown that AMPs are pleiotropic, multifunctional molecules that can strongly modulate immune responses. In this review, we provide a historical overview of the immunomodulatory properties of natural and synthetic antimicrobial peptides, with a special focus on human cathelicidin and defensins. We also summarize the various mechanisms of A ...[more]