DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.
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ABSTRACT:
SUBMITTER: Tindula G
PROVIDER: S-EPMC6088267 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.
Tindula Gwen G Murphy Susan K SK Grenier Carole C Huang Zhiqing Z Huen Karen K Escudero-Fung Maria M Bradman Asa A Eskenazi Brenda B Hoyo Cathrine C Holland Nina N
Epigenomics 20180629 7
<h4>Aim</h4>Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation.<h4>Materials & methods</h4>We quantified DNA methylation of nine imprinted gene differentially methylated regions by pyrosequencing in 296 cord blood DNA samples in a Mexican-American cohort. Fetal exposure was estimated by pht ...[more]
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