Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC6088273 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Liu Qingzhong Q Zheng Zhaojun Z Kim Wooseong W Burgwyn Fuchs Beth B Mylonakis Eleftherios E
Future medicinal chemistry 20180530 11
<h4>Aim</h4>l-benzyl-3-cetyl-2-methylimidazolium iodide (NH125) can inhibit Staphylococcus aureus growth. We investigated the effects of sub-MIC concentrations of NH125 on S. aureus biofilm and virulence. Methodology & results: Three strains of S. aureus were tested. Sub-lethal concentrations of NH125 repressed biofilm formation. At partial sub-MICs, NH125 downregulated the expression of most virulence, while strain-dependent effects were found in the production of α-hemolysin, δ-hemolysin, coag ...[more]