Ontology highlight
ABSTRACT:
SUBMITTER: Vajda S
PROVIDER: S-EPMC6088748 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Vajda Sandor S Beglov Dmitri D Wakefield Amanda E AE Egbert Megan M Whitty Adrian A
Current opinion in chemical biology 20180523
Many proteins in their unbound structures lack surface pockets appropriately sized for drug binding. Hence, a variety of experimental and computational tools have been developed for the identification of cryptic sites that are not evident in the unbound protein but form upon ligand binding, and can provide tractable drug target sites. The goal of this review is to discuss the definition, detection, and druggability of such sites, and their potential value for drug discovery. Novel methods based ...[more]