Dystonia and ataxia progression in spinocerebellar ataxias.

ABSTRACT:

Background

Dystonia is a common feature in spinocerebellar ataxias (SCAs). Whether the presence of dystonia is associated with different rate of ataxia progression is not known.

Objectives

To study clinical characteristics and ataxia progression in SCAs with and without dystonia.

Methods

We studied 334 participants with SCA 1, 2, 3 and 6 from the Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) and compared the clinical characteristics of SCAs with and without dystonia. We repeatedly measured ataxia progression by the Scale for Assessment and Rating of Ataxia every 6 months for 2 years. Regression models were employed to study the association between dystonia and ataxia progression after adjusting for age, sex and pathological CAG repeats. We used lo

SUBMITTER: Kuo PH 

PROVIDER: S-EPMC6089251 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature