Ontology highlight
ABSTRACT:
SUBMITTER: Onozawa E
PROVIDER: S-EPMC6089567 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Onozawa Erika E Shibayama Haruna H Takada Honami H Imadome Ken-Ichi KI Aoki Sho S Yoshimori Mayumi M Shimizu Norio N Fujiwara Shigeyoshi S Koyama Takatoshi T Miura Osamu O Arai Ayako A
Oncotarget 20180724 57
Chronic active Epstein-Barr virus infection (CAEBV) is a lymphoproliferative disorder characterized by the clonal proliferation of EBV-infected T or NK cells and is related to severe systemic inflammation. This study aims to investigate STAT3 to elucidate the mechanism underlying the CAEBV development. We determined that STAT3 was constitutively activated in EBV-positive T- or NK-cell lines. We also determined that STAT3 was activated in the peripheral blood mononuclear cells (PBMCs) containing ...[more]