Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC6089664 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kim Hanna H Brooks Kristina M KM Tang Cheng Cai CC Wakim Paul P Blake Mary M Brooks Stephen R SR Montealegre Sanchez Gina A GA de Jesus Adriana A AA Huang Yan Y Tsai Wanxia Li WL Gadina Massimo M Prakash Apurva A Janes Jonathan Marcus JM Zhang Xin X Macias William L WL Kumar Parag P Goldbach-Mansky Raphaela R
Clinical pharmacology and therapeutics 20171208 2
Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of the oral Janus kinase (JAK)1/JAK2 inhibitor, baricitinib, in 18 patients with Mendelian interferonopathies who are enrolled in a compassionate use program. Patients received doses between 0.1 to 17 mg per day. Covariates of weight and renal function significantly influenced volume-of-distribution and clearance, respectively. The half-life of baricitinib in patients less than 40 kg was substantially shorter tha ...[more]