Ontology highlight
ABSTRACT:
SUBMITTER: Tikhonov DB
PROVIDER: S-EPMC6090064 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tikhonov Denis B DB Zhorov Boris S BS
Frontiers in pharmacology 20180807
Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in academia and industry. In particular, animal toxins such as tetrodotoxin, saxitoxin, and conotoxins have been used as molecular probes of the channel structure. More recently, X-ray structures of potassium and prokaryotic sodium channels allowed ela ...[more]