CD4 T-cells regulate angiogenesis and myogenesis.
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ABSTRACT:
SUBMITTER: Kwee BJ
PROVIDER: S-EPMC6090550 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
CD4 T-cells regulate angiogenesis and myogenesis.
Kwee Brian J BJ Budina Erica E Najibi Alexander J AJ Mooney David J DJ
Biomaterials 20180606
Ischemic diseases, such as peripheral artery disease, affect millions of people worldwide. While CD4<sup>+</sup> T-cells regulate angiogenesis and myogenesis, it is not understood how the phenotype of these adaptive immune cells regulate these regenerative processes. The secreted factors from different types of CD4<sup>+</sup> T-cells (Th1, Th2, Th17, and Treg) were utilized in a series of in vitro assays and delivered from an injectable alginate biomaterial into a murine model of ischemia to st ...[more]
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