Ontology highlight
ABSTRACT:
SUBMITTER: Courtney NA
PROVIDER: S-EPMC6090561 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Courtney Nicholas A NA Briguglio Joseph S JS Bradberry Mazdak M MM Greer Christina C Chapman Edwin R ER
Neuron 20180510 5
Spontaneous neurotransmitter release (mini) is an important form of Ca<sup>2+</sup>-dependent synaptic transmission that occurs in the absence of action potentials. A molecular understanding of this process requires an identification of the underlying Ca<sup>2+</sup> sensors. Here, we address the roles of the relatively low- and high-affinity Ca<sup>2+</sup> sensors, synapotagmin-1 (syt1) and Doc2α/β, respectively. We found that both syt1 and Doc2 regulate minis, but, surprisingly, their relativ ...[more]