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PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

ABSTRACT: Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicated in the proliferation, apoptosis and metastasis of tumors. PEG10 has been found to be positively expressed in a variety of cancers with seemingly complex expression regulation mechanisms. In this review, we focus on the most vital factors influencing PEG10 expression and recapitulate some of the currently known and potential mechanisms of PEG10 affecting tumor progression, as understanding the molecular regulatory mechanisms of tumor progression can provide potential PEG10 related diagnosis and biomarker specific targeted therapies.

SUBMITTER: Xie T

PROVIDER: S-EPMC6090666 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

Xie Tian T Pan Shan S Zheng Hang H Luo Zilv Z Tembo Kingsley M KM Jamal Muhammad M Yu Zhongyang Z Yu Yao Y Xia Jing J Yin Qian Q Wang Meng M Yuan Wen W Zhang Qiuping Q Xiong Jie J

Cancer cell international 20180813

Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. <i>Paternally expressed gene 10</i> (<i>PEG10</i>), located on human chromosome 7q21.3, has turned out to be an oncogene implicated in the proliferation, apoptosis and metastasis of tumors. PEG10 has been found to be positively expressed in a variety of cancers with seemingly complex expression ...[more]

PMID: 30123090

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Dataset Information

PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

Publications

PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

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