Ontology highlight
ABSTRACT:
SUBMITTER: Taylor S
PROVIDER: S-EPMC6090899 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Taylor Shalina S Dirir Omar O Zamanian Roham T RT Rabinovitch Marlene M Thompson A A Roger AAR
Frontiers in medicine 20180803
Pulmonary arterial hypertension (PAH) is a severe vasculopathy characterized by the presence of fibrotic lesions in the arterial wall and the loss of small distal pulmonary arteries. The vasculopathy is accompanied by perivascular inflammation and increased protease levels, with neutrophil elastase notably implicated in aberrant vascular remodeling. However, the source of elevated elastase levels in PAH remains unclear. A major source of neutrophil elastase is the neutrophil, an understudied cel ...[more]