Ontology highlight
ABSTRACT:
SUBMITTER: Meyers DE
PROVIDER: S-EPMC6092051 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Meyers D E DE Bryan P M PM Banerji S S Morris D G DG
Current oncology (Toronto, Ont.) 20180814 4
Lung cancer is the leading cause of cancer-specific death among Canadians, with non-small-cell lung cancer (nsclc) being the most common histologic variant. Despite advances in the understanding of the molecular biology of nsclc, the survival rate for this malignancy is still poor. It is now understood that, to evade detection and immune clearance, nsclc tumours overexpress the immunosuppressive checkpoint protein programmed death ligand 1 (PD-L1). Inhibiting the PD-1/PD-L1 axis with monoclonal ...[more]