Ontology highlight
ABSTRACT:
SUBMITTER: Prague JK
PROVIDER: S-EPMC6092106 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Prague Julia K JK Roberts Rachel E RE Comninos Alexander N AN Clarke Sophie S Jayasena Channa N CN Mohideen Pharis P Lin Vivian H VH Stern Theresa P TP Panay Nicholas N Hunter Myra S MS Webber Lorraine C LC Dhillo Waljit S WS
Menopause (New York, N.Y.) 20180801 8
<h4>Objective</h4>Seventy percent of postmenopausal women experience vasomotor symptoms, which can be highly disruptive and persist for years. Hormone therapy and other treatments have variable efficacy and/or side effects. Neurokinin B signaling increases in response to estrogen deficiency and has been implicated in hot flash (HF) etiology. We recently reported that a neurokinin 3 receptor (NK3R) antagonist reduces HF in postmenopausal women after 4 weeks of treatment. In this article we report ...[more]