Dataset Information

Whole-body MRI for metastatic cancer detection using T2 -weighted imaging with fat and fluid suppression.

ABSTRACT: PURPOSE:To develop a whole-body MRI technique at 3T with improved lesion conspicuity for metastatic cancer detection using fast, high-resolution and high SNR T2 -weighted (T2 W) imaging with simultaneous fat and fluid suppression. THEORY AND METHODS:The proposed dual-echo T2 -weighted acquisition for enhanced conspicuity of tumors (DETECT) acquires 4 images, in-phase (IP) and out-of-phase (OP) at a short and a long TE using single-shot turbo spin echo. The IP/OP images at the short and long TEs are reconstructed using the standard Dixon and shared-field-map Dixon reconstruction respectively, for robust fat-water separation. An adaptive complex subtraction between the 2 TE water-only images achieves fluid attenuation. DETECT imaging was optimized and evaluated in whole-body imaging of 5 healthy volunteers, and compared against diffusion-weighted imaging with background suppression (DWIBS) in 5 patients with known metastatic renal cell carcinoma. RESULTS:Robust fat-water separation and fluid attenuation were achieved using the shared-field-map Dixon reconstruction and adaptive complex subtraction, respectively. DETECT imaging technique generated co-registered T2 W images with and without fat suppression, heavily T2 W, and fat and fluid suppressed T2 W whole-body images in <7?min. Compared to DWIBS acquired in 17?min, the DETECT imaging achieved better detection and localization of lesions in patients with metastatic cancer. CONCLUSION:DETECT imaging technique generates T2 W images with high resolution, high SNR, minimal geometric distortions, and provides good lesion conspicuity with robust fat and fluid suppression in <7?min for whole-body imaging, demonstrating efficient and reliable metastatic cancer detection at 3T.

SUBMITTER: Wang X

PROVIDER: S-EPMC6092263 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Whole-body MRI for metastatic cancer detection using T<sub>2</sub> -weighted imaging with fat and fluid suppression.

Wang Xinzeng X Pirasteh Ali A Brugarolas James J Rofsky Neil M NM Lenkinski Robert E RE Pedrosa Ivan I Madhuranthakam Ananth J AJ

Magnetic resonance in medicine 20180214 4

<h4>Purpose</h4>To develop a whole-body MRI technique at 3T with improved lesion conspicuity for metastatic cancer detection using fast, high-resolution and high SNR T<sub>2</sub> -weighted (T<sub>2</sub> W) imaging with simultaneous fat and fluid suppression.<h4>Theory and methods</h4>The proposed dual-echo T<sub>2</sub> -weighted acquisition for enhanced conspicuity of tumors (DETECT) acquires 4 images, in-phase (IP) and out-of-phase (OP) at a short and a long TE using single-shot turbo spin e ...[more]

PMID: 29446127

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Project description:BackgroundT2-weighted (T2w) intracranial vessel wall imaging (IVWI) provides good contrast to differentiate intracranial vasculopathies and discriminate various important plaque components. However, the strong cerebrospinal fluid (CSF) signal in T2w images interferes with depicting the intracranial vessel wall. In this study, we propose a T2-prepared sequence for whole-brain IVWI at 3T with CSF suppression.MethodsA preparation module that combines T2 preparation and inversion recovery (T2IR) was used to suppress the CSF signal and was incorporated into the commercial three-dimensional (3D) turbo spin echo sequence-Sampling Perfection with Application optimized Contrast using different flip angle Evolution (SPACE). This new technique (hereafter called T2IR-SPACE) was evaluated on nine healthy volunteers and compared with two other commonly used 3D T2-weighted sequences: T2w-SPACE and FLAIR-SPACE (FLAIR: fluid-attenuated inversion recovery). The signal-to-noise ratios (SNRs) of the vessel wall (VW) and CSF and contrast-to-noise ratios (CNRs) between them were measured and compared among these three T2-weighted sequences. Subjective wall visualization of the three T2-weighted sequences was scored blindly and independently by two radiologists using a four-point scale followed by inter-rater reproducibility analysis. A pilot study of four stroke patients was performed to preliminarily evaluate the diagnostic value of this new sequence, which was compared with two conventional T2-weighted sequences.ResultsT2IR-SPACE had the highest CNR (11.01 ± 6.75) compared with FLAIR-SPACE (4.49 ± 3.15; p < 0.001) and T2w-SPACE (-56.16 ± 18.58; p < 0.001). The subjective wall visualization score of T2IR-SPACE was higher than those of FLAIR-SPACE and T2w-SPACE (T2IR-SPACE: 2.35 ± 0.59; FLAIR-SPACE: 0.52 ± 0.54; T2w-SPACE: 1.67 ± 0.58); the two radiologists' scores showed excellent agreement (ICC = 0.883).ConclusionThe T2IR preparation module markedly suppressed the CSF signal without much SNR loss of the other tissues (i.e., vessel wall, white matter, and gray matter) compared with the IR pulse. Our results suggest that T2IR-SPACE is a potential alternative T2-weighted sequence for assessing intracranial vascular diseases.

Dataset Information

Whole-body MRI for metastatic cancer detection using T2 -weighted imaging with fat and fluid suppression.

Publications

Whole-body MRI for metastatic cancer detection using T<sub>2</sub> -weighted imaging with fat and fluid suppression.

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