An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer.
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ABSTRACT:
SUBMITTER: Madsen JS
PROVIDER: S-EPMC6092375 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer.
Madsen Jonas S JS Hylling Ole O Jacquiod Samuel S Pécastaings Sophia S Hansen Lars H LH Riber Leise L Vestergaard Gisle G Sørensen Søren J SJ
The ISME journal 20180613 9
The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugat ...[more]
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