Ontology highlight
ABSTRACT:
SUBMITTER: Hegner B
PROVIDER: S-EPMC6092400 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hegner Björn B Schaub Theres T Janke Daniel D Zickler Daniel D Lange Claudia C Girndt Matthias M Jankowski Joachim J Schindler Ralf R Dragun Duska D
Scientific reports 20180814 1
Severe vascular calcification develops almost invariably in chronic kidney patients posing a substantial risk to quality of life and survival. This unmet medical need demands identification of novel therapeutic modalities. We aimed to pinpoint components of the uremic microenvironment triggering differentiation of vascular progenitors to calcifying osteoblast-like cells. In an unbiased approach, assessing the individual potency of 63 uremic retention solutes to enhance calcific phenotype convers ...[more]