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Detection of KIT mutations in core binding factor acute myeloid leukemia.

ABSTRACT: We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p?=?0.38) respectively. Leukocytosis???20?×?109 /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia in adults. We conclude that no significant difference is found between KIT mutated and unmutated CBF-AML in adults and pediatrics. Children with CBF-AML present with leukocytosis. t(8;21) is associated with thrombocytopenia.

SUBMITTER: Badr P 

PROVIDER: S-EPMC6092444 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Detection of KIT mutations in core binding factor acute myeloid leukemia.

Badr Passant P   Elsayed Ghada M GM   Eldin Dalia Negm DN   Riad Bahia Y BY   Hamdy Nayera N  

Leukemia research reports 20180721

We have investigated the frequency and the effect of <i>KIT</i> mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of <i>KIT</i> mutations was higher in adults compared to pediatrics (22.9% and 14.7%, <i>p</i> = 0.38) respectively. Leukocytosis ≥ 20 × 10<sup>9</sup> /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia i  ...[more]

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