Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Fernandez S
PROVIDER: S-EPMC6092450 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Fernandez-Fernandez Seila S Bobo-Jimenez Veronica V Requejo-Aguilar Raquel R Gonzalez-Fernandez Silvia S Resch Monica M Carabias-Carrasco Monica M Ros Joaquim J Almeida Angeles A Bolaños Juan P JP
Redox biology 20180807
Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been unambiguously elucidated. Previous attempts to address this issue were approached by fully eliminating glutathione, a strategy causing abrupt lethality or premature neuronal death that led to multiple interpretations. To overcome this drawback, here we aimed to moderately d ...[more]