Ontology highlight
ABSTRACT:
SUBMITTER: Varidaki A
PROVIDER: S-EPMC6092511 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Varidaki Artemis A Hong Ye Y Coffey Eleanor T ET
Frontiers in cellular neuroscience 20180808
Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs. Mostly, they act to stabilize microtubules and inhibit cell division. While not without side effects, new generations of these compounds display improved pharmacokinetic properties and brain penetrance. Neurological disorders are intrinsically associated with microtubule defects, and efforts to reposition microtubule-targeting chemotherapeutic agents for treatment of neurodegenerative and psychiatric illn ...[more]