Dataset Information
BALCONY: an R package for MSA and functional compartments of protein variability analysis.
Ontology highlight
ABSTRACT: Background
Here, we present an R package for entropy/variability analysis that facilitates prompt and convenient data extraction, manipulation and visualization of protein features from multiple sequence alignments. BALCONY can work with residues dispersed across a protein sequence and map them on the corresponding alignment of homologous protein sequences. Additionally, it provides several entropy and variability scores that indicate the conservation of each residue.Results
Our package allows the user to visualize evolutionary variability by locating the positions most likely to vary and to assess mutation candidates in protein engineering.Conclusion
In comparison to other R packages BALCONY allows conservation/variability analysis in context of protein structure with linkage of the appropriate metrics with physicochemical features of user choice.Availability
CRAN project page: https://cran.r-project.org/package=BALCONY and our website: http://www.tunnelinggroup.pl/software/ for major platforms: Linux/Unix, Windows and Mac OS X.
SUBMITTER: Pluciennik A
PROVIDER: S-EPMC6092823 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
BALCONY: an R package for MSA and functional compartments of protein variability analysis.
BMC bioinformatics 20180814 1
<h4>Background</h4>Here, we present an R package for entropy/variability analysis that facilitates prompt and convenient data extraction, manipulation and visualization of protein features from multiple sequence alignments. BALCONY can work with residues dispersed across a protein sequence and map them on the corresponding alignment of homologous protein sequences. Additionally, it provides several entropy and variability scores that indicate the conservation of each residue.<h4>Results</h4>Our ...[more]