Ontology highlight
ABSTRACT:
SUBMITTER: Bai YD
PROVIDER: S-EPMC6093072 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bai Ya-Dan YD Yang Yu-Rong YR Mu Xue-Pan XP Lin Ge G Wang You-Ping YP Jin Sheng S Chen Ying Y Wang Ming-Jie MJ Zhu Yi-Chun YC
Oxidative medicine and cellular longevity 20180801
This study aims to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia (AMI), with a focus on apoptosis, autophagy, and inflammatory cell infiltration, and to detect the role of hydrogen sulfide (H<sub>2</sub>S) in this process. We found that SOD1 knockout (KO) mice showed excessive oxidative stress and exacerbated myocardium injury after AMI. Increased apoptosis and inflammation response in the ischemic myocardium contribute to this deterio ...[more]