Ontology highlight
ABSTRACT:
SUBMITTER: Awan B
PROVIDER: S-EPMC6093088 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Awan Baarkullah B Turkov David D Schumacher Cameron C Jacobo Antonio A McEnerney Amber A Ramsey Ashley A Xu Gege G Park Dayoung D Kalomoiris Stefanos S Yao Wei W Jao Li-En LE Allende Miguel L ML Lebrilla Carlito B CB Fierro Fernando A FA
Stem cell reports 20180705 2
Since hundreds of clinical trials are investigating the use of multipotent stromal cells (MSCs) for therapeutic purposes, effective delivery of the cells to target tissues is critical. We have found an unexplored mechanism, by which basic fibroblast growth factor (FGF2) induces expression of fucosyltransferase 8 (FUT8) to increase core fucosylations of N-linked glycans of membrane-associated proteins, including several integrin subunits. Gain- and loss-of-function experiments show that FUT8 is b ...[more]