Ontology highlight
ABSTRACT:
SUBMITTER: Kanteti R
PROVIDER: S-EPMC6093410 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kanteti Rajani R Dhanasingh Immanuel I El-Hashani Essam E Riehm Jacob J JJ Stricker Thomas T Nagy Stanislav S Zaborin Alexander A Zaborina Olga O Biron David D Alverdy John C JC Im Hae Kyung HK Siddiqui Shahid S Padilla Pamela A PA Salgia Ravi R
Cancer biology & therapy 20160101 1
We previously investigated MET and its oncogenic mutants relevant to lung cancer in C. elegans. The inactive orthlogues of the receptor tyrosine kinase Eph and MET, namely vab-1 and RB2088 respectively, the temperature sensitive constitutively active form of KRAS, SD551 (let-60; GA89) and the inactive c-CBL equivalent mutants in sli-1 (PS2728, PS1258, and MT13032) when subjected to chronic exposure of nicotine resulted in a significant loss in egg-laying capacity and fertility. While the vab-1 m ...[more]