Ontology highlight
ABSTRACT:
SUBMITTER: Holtan SG
PROVIDER: S-EPMC6093743 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Holtan Shernan G SG DeFor Todd E TE Panoskaltsis-Mortari Angela A Khera Nandita N Levine John E JE Flowers Mary E D MED Lee Stephanie J SJ Inamoto Yoshihiro Y Chen George L GL Mayer Sebastian S Arora Mukta M Palmer Jeanne J Cutler Corey S CS Arai Sally S Lazaryan Aleksandr A Newell Laura F LF Jagasia Madan H MH Pusic Iskra I Wood William A WA Renteria Anne S AS Yanik Gregory G Hogan William J WJ Hexner Elizabeth E Ayuk Francis F Holler Ernst E Bunworasate Udomsak U Efebera Yvonne A YA Ferrara James L M JLM Pidala Joseph J Howard Alan A Wu Juan J Bolaños-Meade Javier J Ho Vincent V Alousi Amin A Blazar Bruce R BR Weisdorf Daniel J DJ MacMillan Margaret L ML
Blood advances 20180801 15
Amphiregulin (AREG) is an epidermal growth factor receptor ligand that can restore integrity to damaged intestinal mucosa in murine models of acute graft-versus-host disease (aGVHD). We previously reported that circulating AREG is elevated in late-onset aGVHD (occurring after 100 days posttransplant), but its clinical relevance in the context of aGVHD risk is unknown. We measured AREG in 251 aGVHD onset blood samples from Blood and Marrow Clinical Trials Network (BMT CTN) primary treatment trial ...[more]