Ontology highlight
ABSTRACT:
SUBMITTER: Logue SE
PROVIDER: S-EPMC6093931 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180815 1
Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets and strategies. IRE1 is an endoplasmic reticulum (ER) stress sensor, whose activation is predominantly linked to the resolution of ER stress and, in the case of severe stress, to cell death. Here we demonstrate that constitutive IRE1 RNase activity contributes to basal production of pro-tumorigenic factors IL-6, IL-8, C ...[more]