Releasable and traceless PEGylation of arginine-rich antimicrobial peptides.
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ABSTRACT:
SUBMITTER: Gong Y
PROVIDER: S-EPMC6094173 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Releasable and traceless PEGylation of arginine-rich antimicrobial peptides.
Gong Y Y Andina D D Nahar S S Leroux J-C JC Gauthier M A MA
Chemical science 20170330 5
Arginine-rich antimicrobial peptides (AMPs) are emerging therapeutics of interest. However, their applicability is limited by their short circulation half-life, caused in part by their small size and digestion by blood proteases. This study reports a strategy to temporarily mask arginine residues within AMPs with methoxy poly(ethylene glycol). Based on the reagent used, release of AMPs occurred in hours to days in a completely traceless fashion. <i>In vitro</i>, conjugates were insensitive to se ...[more]
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