Ontology highlight
ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC6094359 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Lu Hongyan H Chelvanambi Sarvesh S Poirier Christophe C Saliba Jacob J March Keith L KL Clauss Matthias M Bogatcheva Natalia V NV
Molecular therapy : the journal of the American Society of Gene Therapy 20180615 8
Influenza A virus (IAV) remains a major worldwide health threat, especially to high-risk populations, including the young and elderly. There is an unmet clinical need for therapy that will protect the lungs from damage caused by lower respiratory infection. Here, we analyzed the role of EMAPII, a stress- and virus-induced pro-inflammatory and pro-apoptotic factor, in IAV-induced lung injury. First, we demonstrated that IAV induces EMAPII surface translocation, release, and apoptosis in cultured ...[more]