Ontology highlight
ABSTRACT:
SUBMITTER: Deng W
PROVIDER: S-EPMC6094382 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Deng Wenjun W Zhu Shan S Zeng Ling L Liu Jiao J Kang Rui R Yang Minghua M Cao Lizhi L Wang Haichao H Billiar Timothy R TR Jiang Jianxin J Xie Min M Tang Daolin D
Cell reports 20180701 2
Sepsis and septic shock are associated with life-threatening organ dysfunction caused by an impaired host response to infections. Although circadian clock disturbance impairs the early inflammatory response, its impact on post-septic immunosuppression remains poorly elucidated. Here, we show that Bmal1, a core circadian clock gene, plays a role in the regulation of host immune responses in experimental sepsis. Mechanistically, Bmal1 deficiency in macrophages increases PKM2 expression and lactate ...[more]