Immune checkpoint inhibitors for hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Jensen CE
PROVIDER: S-EPMC6095178 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Immune checkpoint inhibitors for hepatocellular carcinoma.
Jensen Christopher E CE Loaiza-Bonilla Arturo A Bonilla-Reyes Paula A PA
Hepatic oncology 20160627 3
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide, and advanced HCC generally caries a poor prognosis. The treatment of advanced disease is limited to sorafenib, which provides only a limited improvement in survival, and novel therapies are, thus, sorely needed. Among emerging alternative approaches, immune checkpoint inhibitors are a particularly promising treatment modality. In this review, we summarize current knowledge of the mechanisms for the two primary targets ...[more]
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