High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy.
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ABSTRACT: Aim
To evaluate prognostic significance of DKK1 for hepatocelluar carcinoma.Materials & methods
We enrolled a test cohort consisting of 266 hepatitis virus B-related hepatocelluar carcinoma patients who had undergone hepatectomy and a validation cohort of 95. Associations of DKK1 with overall survival and time to recurrence were determined by Cox proportional hazards regression model.Results
High levels of preoperative serum DKK1 were associated with poor overall survival and higher recurrence rate and DKK1 was an independent prognostic predictor. Moreover, DKK1 maintained ability to predict recurrence for patients with low recurrence risk. Double positives of DKK1 and AFP indicated the worst overall survival and the highest recurrence rate compared with either used alone. Patients with preoperatively and 1-day postoperatively positive DKK1 had higher recurrence rates than those whose values were both negative. Similar results were found in the validation cohort.Conclusion
Serum DKK1 could predict prognosis of hepatocelluar carcinoma after hepatectomy.
SUBMITTER: Shen Q
PROVIDER: S-EPMC6095183 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy.
Shen Qiujin Q Yang Xin-Rong XR Tan Yexiong Y You Haiyan H Xu Yang Y Chu Wei W Ge Tianxiang T Zhou Jian J Qiu Shuang-Jian SJ Shi Ying-Hong YH Zhang Zhigang Z Gu Jianren J Wang Hongyang H Fan Jia J Qin Wenxin W
Hepatic oncology 20150401 3
<h4>Aim</h4>To evaluate prognostic significance of DKK1 for hepatocelluar carcinoma.<h4>Materials & methods</h4>We enrolled a test cohort consisting of 266 hepatitis virus B-related hepatocelluar carcinoma patients who had undergone hepatectomy and a validation cohort of 95. Associations of DKK1 with overall survival and time to recurrence were determined by Cox proportional hazards regression model.<h4>Results</h4>High levels of preoperative serum DKK1 were associated with poor overall survival ...[more]
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