Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6095196 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cell reports 20180701 3
Naive CD4<sup>+</sup> T cells can be converted to Foxp3<sup>+</sup> T regulatory cells (Tregs) in the periphery (iTregs), where induction of Foxp3 gene expression is central to Treg differentiation. OX40 signaling is known to inhibit Foxp3 expression and Treg induction, but the underlying mechanisms remain poorly defined. Here, we found that OX40 costimulation activates two distinct molecular pathways to suppress Foxp3 expression in freshly activated naive CD4<sup>+</sup> T cells. Specifically, ...[more]