Ontology highlight
ABSTRACT:
SUBMITTER: Braak H
PROVIDER: S-EPMC6095209 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cerebral cortex (New York, N.Y. : 1991) 20180901 9
By using AT8-immunocytochemistry that visualizes hyperphosphorylated tau protein, we examined neurofibrillary changes related to sporadic Alzheimer's disease (AD) in N = 40 individuals at neurofibrillary tangle (NFT) stages I-IV. We report the presence of abnormal tau changes within solitary pyramidal neurons in layers III and V of the neocortex. These pyramidal cells showed pathology in different cell compartments (dendritic, somatic, axonal) that appeared to occur sequentially: Tau pathology w ...[more]