Ontology highlight
ABSTRACT:
SUBMITTER: Moreno-Caceres J
PROVIDER: S-EPMC6095415 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Moreno-Càceres Joaquim J Fabregat Isabel I
Hepatic oncology 20151001 4
Hepatocellular carcinoma (HCC) is a major health problem. In human hepatocarcinogenesis, the balance between cell death and proliferation is deregulated, tipping the scales for a situation where antiapoptotic signals are overpowering the death-triggering stimuli. HCC cells harbor a wide variety of mutations that alter the regulation of apoptosis and hence the response to chemotherapeutical drugs, making them resistant to the proapoptotic signals. Considering all these modifications found in HCC ...[more]