Ontology highlight
ABSTRACT:
SUBMITTER: Shentu YP
PROVIDER: S-EPMC6095478 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cell reports 20180701 3
Protein phosphatase 2A (PP2A) inhibition causes hyperphosphorylation of tau and APP in Alzheimer's disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear. We demonstrate that Cancerous Inhibitor of PP2A (CIP2A), an endogenous PP2A inhibitor, is overexpressed in AD brain. CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP β-cleavage and Aβ production. Increase in CIP2A expression also leads to tau mislocali ...[more]