Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.

ABSTRACT:

Objectives

To employ metabolomics-based pathway and network analyses to evaluate the cerebrospinal fluid metabolome after severe traumatic brain injury in children and the capacity of combination therapy with probenecid and N-acetylcysteine to impact glutathione-related and other pathways and networks, relative to placebo treatment.

Design

Analysis of cerebrospinal fluid obtained from children enrolled in an Institutional Review Board-approved, randomized, placebo-controlled trial of a combination of probenecid and N-acetylcysteine after severe traumatic brain injury (Trial Registration NCT01322009).

Setting

Thirty-six-bed PICU in a university-affiliated children's hospital.

Patients and subjects

Twelve children 2-18 years old after severe traumatic brain injur

SUBMITTER: Hagos FT 

PROVIDER: S-EPMC6095742 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature