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Effects of Rifaximin on Central Responses to Social Stress-a Pilot Experiment.

ABSTRACT: Probiotics that promote the gut microbiota have been reported to reduce stress responses, and improve memory and mood. Whether and how antibiotics that eliminate or inhibit pathogenic and commensal gut bacteria also affect central nervous system functions in humans is so far unknown. In a double-blinded randomized study, 16 healthy volunteers (27.00 ± 1.60 years; 9 males) received either rifaximin (600 mg/day) (a poorly absorbable antibiotic) or placebo for 7 days. Before and after the drug intervention, brain activities during rest and during a social stressor inducing feelings of exclusion (Cyberball game) were measured using magnetoencephalography. Social exclusion significantly affected (p?

SUBMITTER: Wang H

PROVIDER: S-EPMC6095772 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Effects of Rifaximin on Central Responses to Social Stress-a Pilot Experiment.

Wang Huiying H Braun Christoph C Enck Paul P

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20180701 3

Probiotics that promote the gut microbiota have been reported to reduce stress responses, and improve memory and mood. Whether and how antibiotics that eliminate or inhibit pathogenic and commensal gut bacteria also affect central nervous system functions in humans is so far unknown. In a double-blinded randomized study, 16 healthy volunteers (27.00 ± 1.60 years; 9 males) received either rifaximin (600 mg/day) (a poorly absorbable antibiotic) or placebo for 7 days. Before and after the drug inte ...[more]

PMID: 29713909

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