Ontology highlight
ABSTRACT:
SUBMITTER: Skorput AGJ
PROVIDER: S-EPMC6095807 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Skorput Alexander G J AGJ Zhang Xijing X Waataja Jonathan J JJ Peterson Cristina D CD Riedl Maureen S MS Kitto Kelley F KF Truong Hai H Huffman Cecilia C Salton Stephen R SR Fairbanks Carolyn A CA Honda Christopher N CN Vulchanova Lucy L
Pain 20180901 9
Neuroplasticity in the dorsal horn after peripheral nerve damage contributes critically to the establishment of chronic pain. The neurosecretory protein VGF (nonacronymic) is rapidly and robustly upregulated after nerve injury, and therefore, peptides generated from it are positioned to serve as signals for peripheral damage. The goal of this project was to understand the spinal modulatory effects of the C-terminal VGF-derived peptide TLQP-62 at the cellular level and gain insight into the funct ...[more]