Ontology highlight
ABSTRACT:
SUBMITTER: Campinho MA
PROVIDER: S-EPMC6095868 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Campinho Marco A MA Silva Nádia N Martins Gabriel G GG Anjos Liliana L Florindo Claudia C Roman-Padilla Javier J Garcia-Cegarra Ana A Louro Bruno B Manchado Manuel M Power Deborah M DM
Scientific reports 20180816 1
Flatfish metamorphosis is a unique post-embryonic developmental event in which thyroid hormones (THs) drive the development of symmetric pelagic larva into asymmetric benthic juveniles. One of the eyes migrates to join the other eye on the opposite side of the head. Developmental mechanisms at the basis of the acquisition of flatfish anatomical asymmetry remain an open question. Here we demonstrate that an TH responsive asymmetric centre, determined by deiodinase 2 expression, ventrally juxtapos ...[more]