Ontology highlight
ABSTRACT:
SUBMITTER: Perez B
PROVIDER: S-EPMC6095910 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pérez Bianca B Coletta Andrea A Pedersen Jannik N JN Petersen Steen V SV Periole Xavier X Pedersen Jan Skov JS Sessions Richard B RB Guo Zheng Z Perriman Adam A Schiøtt Birgit B
Scientific reports 20180816 1
Bioconjugates established between anionic polyethylene glycol (PEG) based polymers and cationic proteins have proven to be a promising strategy to engineer thermostable biocatalysts. However, the enzyme activity of these bioconjugates is very low and the mechanism of non-covalent PEG-stabilization is yet to be understood. This work presents experimental and molecular dynamics simulation studies, using lipase-polymer surfactant nanoconjugates from mesophile Rhizomucor miehei (RML), performed to e ...[more]