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ABSTRACT: Objectives
To assesses whether automated brain image analysis with quantification of structural brain changes improves diagnostic accuracy in a memory clinic setting.Methods
In 42 memory clinic patients, we evaluated whether automated quantification of brain tissue volumes, hippocampal volume and white matter lesion volume improves diagnostic accuracy for Alzheimer's disease (AD) and frontotemporal dementia (FTD), compared to visual interpretation. Reference data were derived from a dementia-free aging population (n?=?4915, aged >45?years), and were expressed as age- and sex-specific percentiles. Experienced radiologists determined the most likely imaging-based diagnosis based on structural brain MRI using three strategies (visual assessment of MRI only, quantitative normative information only, or a combination of both). Diagnostic accuracy of each strategy was calculated with the clinical diagnosis as the reference standard.Results
Providing radiologists with only quantitative data decreased diagnostic accuracy both for AD and FTD compared to conventional visual rating. The combination of quantitative with visual information, however, led to better diagnostic accuracy compared to only visual ratings for AD. This was not the case for FTD.Conclusion
Quantitative assessment of structural brain MRI combined with a reference standard in addition to standard visual assessment may improve diagnostic accuracy in a memory clinic setting.
SUBMITTER: Vernooij MW
PROVIDER: S-EPMC6096052 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Vernooij Meike W MW Jasperse Bas B Steketee Rebecca R Koek Marcel M Vrooman Henri H Ikram M Arfan MA Papma Janne J van der Lugt Aad A Smits Marion M Niessen Wiro J WJ
NeuroImage. Clinical 20180809
<h4>Objectives</h4>To assesses whether automated brain image analysis with quantification of structural brain changes improves diagnostic accuracy in a memory clinic setting.<h4>Methods</h4>In 42 memory clinic patients, we evaluated whether automated quantification of brain tissue volumes, hippocampal volume and white matter lesion volume improves diagnostic accuracy for Alzheimer's disease (AD) and frontotemporal dementia (FTD), compared to visual interpretation. Reference data were derived fro ...[more]