Genetic findings in sport-related concussions: potential for individualized medicine?
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ABSTRACT:
SUBMITTER: McDevitt J
PROVIDER: S-EPMC6096436 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Genetic findings in sport-related concussions: potential for individualized medicine?
McDevitt Jane J Krynetskiy Evgeny E
Concussion (London, England) 20170124 1
Concussion is a traumatic transient disturbance of the brain. In sport, the initial time and severity of concussion is known giving an opportunity for subsequent analysis. Variability in susceptibility and recovery between individual athletes depends, among other parameters, on genetic factors. The genes-encoding polypeptides that determine incidence, severity and prognosis for concussion are the primary candidates for genetic analysis. Genetic polymorphisms in the genes contributing to plastici ...[more]
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Project description:The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.
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