Magnesium deficiency prevents high-fat-diet-induced obesity in mice.

ABSTRACT: AIMS/HYPOTHESIS:Hypomagnesaemia (blood Mg2+ <0.7 mmol/l) is a common phenomenon in individuals with type 2 diabetes. However, it remains unknown how a low blood Mg2+ concentration affects lipid and energy metabolism. Therefore, the importance of Mg2+ in obesity and type 2 diabetes has been largely neglected to date. This study aims to determine the effects of hypomagnesaemia on energy homeostasis and lipid metabolism. METHODS:Mice (n?=?12/group) were fed either a low-fat diet (LFD) or a high-fat diet (HFD) (10% or 60% of total energy) in combination with a normal- or low-Mg2+ content (0.21% or 0.03% wt/wt) for 17 weeks. Metabolic cages were used to investigate food intake, energy expenditure and respiration. Blood and tissues were taken to study metabolic parameters and mRNA expression profiles, respectively. RESULTS:We show that low dietary Mg2+ intake ameliorates HFD-induced obesity in mice (47.00?±?1.53 g vs 38.62?±?1.51 g in mice given a normal Mg2+-HFD and low Mg2+-HFD, respectively, p?

SUBMITTER: Kurstjens S 

PROVIDER: S-EPMC6096631 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature