Ontology highlight
ABSTRACT:
SUBMITTER: Haywood T
PROVIDER: S-EPMC6096773 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Haywood Tom T Cesarec Sara S Kealey Steven S Plisson Christophe C Miller Philip W PW
MedChemComm 20180702 8
Herein we report the preparation of ammonium [<sup>11</sup>C]thiocyanate <i>via</i> the reaction of [<sup>11</sup>C]CS<sub>2</sub> with ammonia. The [<sup>11</sup>C]SCN<sup>-</sup> ion is demonstrated as a potent nucleophile that can be used to readily generate a range of <sup>11</sup>C-labelled thiocyanate molecules in high conversions. Furthermore, novel <sup>11</sup>C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones <i>via</i> an acid mediated c ...[more]