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Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling.


ABSTRACT: Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammonia. The [11C]SCN- ion is demonstrated as a potent nucleophile that can be used to readily generate a range of 11C-labelled thiocyanate molecules in high conversions. Furthermore, novel 11C-labelled thiazolone molecules can be easily prepared from the intermediate ?-thiocyanatophenones via an acid mediated cyclisation reaction.

SUBMITTER: Haywood T 

PROVIDER: S-EPMC6096773 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Ammonium [<sup>11</sup>C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling.

Haywood Tom T   Cesarec Sara S   Kealey Steven S   Plisson Christophe C   Miller Philip W PW  

MedChemComm 20180702 8


Herein we report the preparation of ammonium [<sup>11</sup>C]thiocyanate <i>via</i> the reaction of [<sup>11</sup>C]CS<sub>2</sub> with ammonia. The [<sup>11</sup>C]SCN<sup>-</sup> ion is demonstrated as a potent nucleophile that can be used to readily generate a range of <sup>11</sup>C-labelled thiocyanate molecules in high conversions. Furthermore, novel <sup>11</sup>C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones <i>via</i> an acid mediated c  ...[more]

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