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Ammonium [¹¹C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling.

ABSTRACT: Herein we report the preparation of ammonium [¹¹C]thiocyanate via the reaction of [¹¹C]CS₂ with ammonia. The [¹¹C]SCN^- ion is demonstrated as a potent nucleophile that can be used to readily generate a range of ¹¹C-labelled thiocyanate molecules in high conversions. Furthermore, novel ¹¹C-labelled thiazolone molecules can be easily prepared from the intermediate ?-thiocyanatophenones via an acid mediated cyclisation reaction.

SUBMITTER: Haywood T

PROVIDER: S-EPMC6096773 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling.

Haywood Tom T Cesarec Sara S Kealey Steven S Plisson Christophe C Miller Philip W PW

MedChemComm 20180702 8

Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammonia. The [11C]SCN- ion is demonstrated as a potent nucleophile that can be used to readily generate a range of 11C-labelled thiocyanate molecules in high conversions. Furthermore, novel 11C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated c ...[more]

PMID: 30151085

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