Ontology highlight
ABSTRACT:
SUBMITTER: da Cunha Colombo Bonadio RR
PROVIDER: S-EPMC6096977 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Clinics (Sao Paulo, Brazil) 20180820 suppl 1
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed. Germline mutations in the BRCA 1/2 genes are the most well-known mechanisms of homologous recombination deficiency. However, other mechanisms, such as germline and somatic mutations in other homologous recombination genes and epigenetic modifications ...[more]