Ontology highlight
ABSTRACT:
SUBMITTER: Wiedemann B
PROVIDER: S-EPMC6097187 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wiedemann Bianca B Weisner Jörn J Rauh Daniel D
MedChemComm 20180711 8
Transcription factors (TFs) constitute a diverse class of sequence-specific DNA-binding proteins, which are key to the modulation of gene expression. TFs have been associated with human diseases, including cancer, Alzheimer's and other neurodegenerative diseases, which makes this class of proteins attractive targets for chemical biology and medicinal chemistry research. Since TFs lack a common binding site or structural similarity, the development of small molecules to efficiently modulate TF bi ...[more]