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Chemical modulation of transcription factors.


ABSTRACT: Transcription factors (TFs) constitute a diverse class of sequence-specific DNA-binding proteins, which are key to the modulation of gene expression. TFs have been associated with human diseases, including cancer, Alzheimer's and other neurodegenerative diseases, which makes this class of proteins attractive targets for chemical biology and medicinal chemistry research. Since TFs lack a common binding site or structural similarity, the development of small molecules to efficiently modulate TF biology in cells and in vivo is a challenging task. This review highlights various strategies that are currently being explored for the identification and development of modulators of Myc, p53, Stat, Nrf2, CREB, ER, AR, HIF, NF-?B, and BET proteins.

SUBMITTER: Wiedemann B 

PROVIDER: S-EPMC6097187 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Chemical modulation of transcription factors.

Wiedemann Bianca B   Weisner Jörn J   Rauh Daniel D  

MedChemComm 20180711 8


Transcription factors (TFs) constitute a diverse class of sequence-specific DNA-binding proteins, which are key to the modulation of gene expression. TFs have been associated with human diseases, including cancer, Alzheimer's and other neurodegenerative diseases, which makes this class of proteins attractive targets for chemical biology and medicinal chemistry research. Since TFs lack a common binding site or structural similarity, the development of small molecules to efficiently modulate TF bi  ...[more]

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